期刊
NEUROBIOLOGY OF AGING
卷 90, 期 -, 页码 75-83出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2020.01.011
关键词
MRI; Hippocampal subfields; Aging; Alzheimer's disease
资金
- Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Fondation Plan Alzheimer
- Caisse Nationale de Solidarite pour l'Autonomie (CNSA)
- French National Research Agency [ANR-18-CE45-0013]
- Ministerio de Economia, Industria y Competitividad of Spain [DPI2017-87743-R]
- Investments for the future Program IdEx Bordeaux (HL-MRI Project) [ANR10-IDEX-03-02]
- Fondation Bettencourt Schueller (CCA-Inserm-Bettencourt)
- Ministry of Research-INSERM Programme Cohortes et collections de donnees biologiques
- Laboratory of Excellence TRAIL [ANR-10-LABX-57]
- Direction Generale de la Sante
- Mutuelle Generale de l'Education Nationale
- Institut de la Longevite
- Conseils Regionaux d'Aquitaine et Bourgogne
- Fondation de France
- [ANR 2007LVIE 003]
- Agence Nationale de la Recherche (ANR) [ANR-18-CE45-0013] Funding Source: Agence Nationale de la Recherche (ANR)
Several studies have investigated the differential vulnerability of hippocampal subfields during aging and Alzheimer's disease (AD). Results were often contradictory, mainly because these works were based on concatenations of cross-sectional measures in cohorts with different ages or stages of AD, in the absence of a longitudinal design. Here, we investigated 327 participants from a population-based cohort of nondemented older adults with a 14-year clinical follow-up. MRI at baseline and 4 years later were assessed to measure the annualized rates of hippocampal subfields atrophy in each participant using an automatic segmentation pipeline with subsequent quality control. On the one hand, CA4 dentate gyrus was significantly more affected than the other subfields in the whole population (CA1-3: -0.68%/year; subiculum: -0.99%/year; and CA4-DG: -1.39%/year; p < 0.0001). On the other hand, the annualized rate of CA1-3 atrophy was associated with an increased risk of developing Alzheimer's clinical syndrome over time, independently of age, gender, educational level, and ApoE4 genotype (HR = 2.0; CI 95% 1.4-3.0). These results illustrate the natural history of hippocampal subfields atrophy during aging and AD by showing that the dentate gyrus is the most vulnerable subfield to the effects of aging while the cornu-ammonis is the primary target of AD pathophysiological processes, years before symptom onset. (C) 2020 Elsevier Inc. All rights reserved.
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