期刊
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
卷 17, 期 1, 页码 53-64出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41575-019-0242-7
关键词
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资金
- NIH [R01DK073338, R01AT008623]
- University of Florida Department of Medicine Gatorade Fund
- American Cancer Society Norma and Rich DiMarco Mentored Research Scholar Grant [MRSG-17-228-01-TBG]
- University of Florida Health Cancer Center Pilot Project Grant
Diseases intrinsic to the pancreas such as pancreatitis, pancreatic cancer and type 1 diabetes mellitus impart substantial health and financial burdens on society but identification of novel mechanisms contributing to these pathologies are slow to emerge. A novel area of research suggests that pancreatic-specific disorders might be modulated by the gut microbiota, either through a local (direct pancreatic influence) or in a remote (nonpancreatic) fashion. In this Perspectives, we examine literature implicating microorganisms in diseases of the pancreas, specifically pancreatitis, type 1 diabetes mellitus and pancreatic ductal adenocarcinoma. We also discuss evidence of an inherent pancreatic microbiota and the influence of the intestinal microbiota as it relates to disease associa-tion and development. In doing so, we address pitfalls in the current literature and areas of investigation that are needed to advance a developing field of research that has clinical potential to reduce the societal burden of pancreatic diseases.
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