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NEW ENGLAND JOURNAL OF MEDICINE (2011)
The von Willebrand Inhibitor ARC1779 Reduces Cerebral Embolization After Carotid Endarterectomy A Randomized Trial
Hugh S. Markus et al.
STROKE (2011)
Vitamin K Antagonists - Current Concepts and Challenges
Hayan Moualla et al.
THROMBOSIS RESEARCH (2011)
The influence of CYP 2C19*2 polymorphism on platelet function testing during single antiplatelet treatment with clopidogrel
Alf-Aage R. Pettersen et al.
THROMBOSIS JOURNAL (2011)
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo
Qiufang Cheng et al.
BLOOD (2010)
Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
Valerie Martin et al.
BLOOD (2010)
Tolerability and Pharmacokinetics of TB-402 in Healthy Male Volunteers
Peter Verhamme et al.
CLINICAL THERAPEUTICS (2010)
Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease
Shinya Goto et al.
EUROPEAN HEART JOURNAL (2010)
A 2-Step Mechanism of Arterial Thrombus Formation Induced by Human Atherosclerotic Plaques
Armin J. Reininger et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
Lee A. Honigberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Targeting von Willebrand factor and platelet glycoprotein Ib receptor
Christa Firbas et al.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY (2010)
JAK2V617F mutation for the early diagnosis of Ph- myeloproliferative neoplasms in patients with venous thromboembolism: a meta-analysis
Francesco Dentali et al.
BLOOD (2009)
A multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial assessing safety and efficacy of active site inactivated recombinant factor VIIa in subjects with acute lung injury or acute respiratory distress syndrome
Jean-Louis Vincent et al.
CRITICAL CARE MEDICINE (2009)
Venous and arterial thrombosis: Two aspects of the same disease?
Paolo Prandoni
EUROPEAN JOURNAL OF INTERNAL MEDICINE (2009)
Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model
M. J. E. Kuijpers et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)
Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited
Timothy Watson et al.
LANCET (2009)
Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial
Gilles Montalescot et al.
LANCET (2009)
Dabigatran versus Warfarin in Patients with Atrial Fibrillation.
Stuart J. Connolly et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes
Lars Wallentin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Tissue Factor in Brain Is Not Saturated With Factor VIIa Implications for Factor VIIa Dosing in Intracerebral Hemorrhage
Maureane Hoffman et al.
STROKE (2009)
Tissue factor activity of blood mononuclear cells is increased after total knee arthroplasty
Gerhard J. Johnson et al.
THROMBOSIS AND HAEMOSTASIS (2009)
Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo
Christian Schulz et al.
BASIC RESEARCH IN CARDIOLOGY (2008)
Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: an exploratory study
B. I. Eriksson et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
Family history of myocardial infarction is an independent risk factor for venous thromboembolism: the Tromso study
S. K. Braekkan et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
Triggers, targets and treatments for thrombosis
Nigel Mackman
NATURE (2008)
Glycoprotein Ibα and von Willebrand factor in primary platelet adhesion and thrombus formation:: Lessons from mutant mice
Wolfgang Bergmeier et al.
THROMBOSIS AND HAEMOSTASIS (2008)
Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues
Brian F. Gage et al.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2008)
First-in-human evaluation of anti-von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers
James C. Gilbert et al.
CIRCULATION (2007)
Prasugrel versus clopidogrel in patients with acute coronary syndromes
Stephen D. Wiviott et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Platelet glycoprotein VI-related clinical defects
Jane F. Arthur et al.
BRITISH JOURNAL OF HAEMATOLOGY (2007)
Estimation of warfarin maintenance dose based on VKORCI (-1639 G>A) and CYP2C9 genotypes
Yusheng Zhu et al.
CLINICAL CHEMISTRY (2007)
Tissue factor around dermal vessels has bound factor VII in the absence of injury
M. Hoffman et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
Recombinant nematode anticoagulant protein c2 in patients with non-ST-Segment elevation acute coronary syndrome - The ANTHEM-TIMI-32 trial
Robert P. Giugliano et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)
The intrinsic pathway of coagulation:: a target for treating thromboembolic disease?
D. Gailani et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology - A phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity
Christopher K. Dyke et al.
CIRCULATION (2006)
Cytochrorne P4502C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
Jean-Sebastien Hulot et al.
BLOOD (2006)
Venous thromboembolism and the risk of subsequent symptomatic atherosclerosis
P. Prandoni et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2006)
Prospective study of subclinical atherosclerosis as a risk factor for venous thromboembolism
L. M. Reich et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2006)
Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment
Dominick J. Angiolillo et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)
Conformation-specific blockade of the integrin GPIIb/IIIa - A novel antiplatelet strategy that selectively targets activated platelets
Meike Schwarz et al.
CIRCULATION RESEARCH (2006)
Structure and function of the platelet integrin αIIbβ3
JS Bennett
JOURNAL OF CLINICAL INVESTIGATION (2005)
Tissue-specific hemostasis in mice
N Mackman
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: Meta-analysis with estimates of risk and benefit
MB Rothberg et al.
ANNALS OF INTERNAL MEDICINE (2005)
Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation
SC Robson et al.
SEMINARS IN THROMBOSIS AND HEMOSTASIS (2005)
Historical analysis of PAI-I from its discovery to its potential role in cell motility and disease
C Dellas et al.
THROMBOSIS AND HAEMOSTASIS (2005)
Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice
S Grüner et al.
BLOOD (2005)
Integrins: dynamic scaffolds for adhesion and signaling in platelets
SJ Shattil et al.
BLOOD (2004)
Risk of bleeding complications with antiplatelet agents: Meta-analysis of 338,191 patients enrolled in 50 randomized controlled trials
VL Serebruany et al.
AMERICAN JOURNAL OF HEMATOLOGY (2004)
Oral GPIIb/IIIa antagonists: What went wrong?
D Cox
CURRENT PHARMACEUTICAL DESIGN (2004)
Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy
EP McFadden et al.
LANCET (2004)
Blocking receptors on the inside: pepducin-based intervention of PAR signaling and thrombosis
A Kuliopulos et al.
LIFE SCIENCES (2003)
Platelet-collagen interaction: is GPVI the central receptor?
B Nieswandt et al.
BLOOD (2003)
Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation
L Covic et al.
NATURE MEDICINE (2002)
Effect of a humanized monoclonal antibody to von Willebrand factor in a canine model of coronary arterial thrombosis
S Kageyama et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
The Vitamin K-dependent carboxylase
SR Presnell et al.
THROMBOSIS AND HAEMOSTASIS (2002)
Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans
FS Chow et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2002)
Inhibition of factor IX(a) is protective in a rat model of thromboembolic stroke
JR Toomey et al.
STROKE (2002)
Fondaparinux: a synthetic heparin pentasaccharide as a new antithrombotic agent
JM Walenga et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2002)
Pharmacokinetics and pharmacodynamics of AJW200, a humanized monoclonal antibody to von Willebrand factor, in monkeys
S Kageyama et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)
Bruton's tyrosine kinase is present in normal platelets and its absence identifies patients with X-linked agammaglobulinaemia and carrier females
T Futatani et al.
BRITISH JOURNAL OF HAEMATOLOGY (2001)
Noninvasive follow-up of GDC-treated saccular aneurysms by MR angiography
W Weber et al.
EUROPEAN RADIOLOGY (2001)
Comparing the antithrombotic efficacy of a humanized anti-factor IX(a) monoclonal antibody (SB 249417) to the low molecular weight heparin enoxaparin in a rat model of arterial thrombosis
JR Toomey et al.
THROMBOSIS RESEARCH (2000)
Thrombin signalling and protease-activated receptors
SR Coughlin
NATURE (2000)
PAR3 is a cofactor for PAR4 activation by thrombin
M Nakanishi-Matsui et al.
NATURE (2000)
Regulation of blood coagulation
CT Esmon
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (2000)