4.6 Review

Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

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Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2008)

Article Cell Biology

Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis

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+647 A/C and +1245 MT1A polymorphisms of diabetes mellitus and cardiovascular in the susceptibility complications

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Insulin-Treated Type 2 Diabetes Is Associated with a Decreased Survival in Heart Failure Patients after Cardiac Resynchronization Therapy

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PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2008)

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Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy

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NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE (2008)

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Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy

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BASIC RESEARCH IN CARDIOLOGY (2007)

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Improved glucose Homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B

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MOLECULAR AND CELLULAR BIOLOGY (2007)

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Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

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NATURE MEDICINE (2007)

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Markers of inflammation and fibrosis are related to cardiovascular damage in hypertensive patients with metabolic syndrome

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AMERICAN JOURNAL OF HYPERTENSION (2007)

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The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people

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MOLECULAR MEDICINE (2007)

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NATURE REVIEWS IMMUNOLOGY (2007)

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CD36 deficiency rescues lipotoxic cardiomyopathy

John Yang et al.

CIRCULATION RESEARCH (2007)

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Serum zinc level and coronary heart disease events in patients with type 2 diabetes

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DIABETES CARE (2007)

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N-acetylcysteine attenuates PKCβ2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats

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CARDIOVASCULAR RESEARCH (2007)

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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NATURE (2006)

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Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue

C Kurlawalla-Martinez et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

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Muscle-specific Pten deletion protects against insulin resistance and diabetes

N Wijesekara et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

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Screening for heart disease in diabetic subjects

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AMERICAN HEART JOURNAL (2005)

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RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages

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SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2005)

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ENDOCRINE REVIEWS (2004)

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Live-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Overexpression of metallothionein reduces diabetic cardiomyopathy

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Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase

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Leukemia inhibitory factor and interleukin-6 downregulate sarcoplasmic reticulum Ca2+ ATPase (SERCA2) in cardiac myocytes

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