期刊
NATURE NEUROSCIENCE
卷 23, 期 2, 页码 172-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41593-019-0569-y
关键词
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资金
- MRC-LMB Electron Microscopy Facility
- Novo Nordisk Foundation [NNF17OC0030788]
- National Institute of General Medical Sciences [R35-GM122550]
- National Institute of Mental Health [R01-MH112766]
- Chan Zuckerberg Initiative
- MRC [MC_UP_1201/16]
- MRC [MC_UP_1201/16] Funding Source: UKRI
Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.
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