期刊
NATURE NANOTECHNOLOGY
卷 14, 期 12, 页码 1093-1103出版社
NATURE PORTFOLIO
DOI: 10.1038/s41565-019-0589-5
关键词
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资金
- National Natural Science Foundation of China [51673185, 51973215]
- Carolina Center of Cancer Nanotechnology Excellence (C-CCNE) Pilot Grant Program - National Institutes of Health (NIH) National Cancer Institute [5U54CA198999-04]
- NIH [CA198999]
The microbiome is emerging as a key player and driver of cancer. Traditional modalities to manipulate the microbiome (for example, antibiotics, probiotics and microbiota transplants) have been shown to improve efficacy of cancer therapies in some cases, but issues such as collateral damage to the commensal microbiota and consistency of these approaches motivates efforts towards developing new technologies specifically designed for the microbiome-cancer interface. Considering the success of nanotechnology in transforming cancer diagnostics and treatment, nanotechnologies capable of manipulating interactions that occur across microscopic and molecular length scales in the microbiome and the tumour microenvironment have the potential to provide innovative strategies for cancer treatment. As such, opportunities at the intersection of nanotechnology, the microbiome and cancer are massive. In this Review, we highlight key opportunistic areas for applying nanotechnologies towards manipulating the microbiome for the treatment of cancer, give an overview of seminal work and discuss future challenges and our perspective on this emerging area.
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