期刊
NATURE MEDICINE
卷 25, 期 12, 页码 1822-1832出版社
NATURE PORTFOLIO
DOI: 10.1038/s41591-019-0675-0
关键词
-
资金
- National Institutes of Health (NIH)
- Buck Institute for Research on Aging
- National Institute on Aging
- Glenn Foundation
- SENS Foundation
- Ministry of Education and Science of the Russian Federation [074-02-2018-330]
- Horizon 2020 Framework Programme [634821]
- JPco-fuND (ADAGE)
- National Institute of Aging, NIH
- MRC (UK)
- Wellcome Trust
- NIH [R01 DK104344, P01 AG036695, K08 MH103443]
- European Research Commission [PHII-669415]
- Associazione Italiana Ricerca sul Cancro [IG 19014, 5x1000 9962, 21147]
- Fondazione Cariplo
- Italian Ministry of Health
- UCLA AIDS Institute
- Spanish Ministry of Economy and Competitiveness
- Fondos FEDER [PI15/00558, PI18/00139]
- Society in Science-Branco Weiss Fellowship
- Brain & Behavior Research Foundation [23958]
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据