期刊
NATURE IMMUNOLOGY
卷 21, 期 3, 页码 343-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41590-020-0602-z
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资金
- Wellcome Trust [WT206194]
- European Research Council [646794 ThDEFINE]
- Christ's College, University of Cambridge
- European Union's H2020 research and innovation programme `ENLIGHT-TEN' under Marie Sklodowska-Curie grant [675395]
- Sir Henry Wellcome Postdoctoral Fellowship [213555/Z/18/Z]
- NIHR Cambridge Biomedical Research Centre [RG92051]
- Wellcome Trust [213555/Z/18/Z] Funding Source: Wellcome Trust
Gastrointestinal microbiota and immune cells interact closely and display regional specificity; however, little is known about how these communities differ with location. Here, we simultaneously assess microbiota and single immune cells across the healthy, adult human colon, with paired characterization of immune cells in the mesenteric lymph nodes, to delineate colonic immune niches at steady state. We describe distinct helper T cell activation and migration profiles along the colon and characterize the transcriptional adaptation trajectory of regulatory T cells between lymphoid tissue and colon. Finally, we show increasing B cell accumulation, clonal expansion and mutational frequency from the cecum to the sigmoid colon and link this to the increasing number of reactive bacterial species. The gut microbiota and their proximate immune cells engage in a dialog of reciprocal regulation. James and colleagues describe how immune cell and microbiotal populations vary along the length of the human colon.
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