期刊
NATURE
卷 579, 期 7798, 页码 270-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41586-020-2012-7
关键词
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资金
- Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) [XDB29010101, XDB29010104]
- China Natural Science Foundation for excellent scholars [81822028, 31770175, 31800142]
- Mega-Project for Infectious Disease from Minister of Science and Technology of the People's Republic of China [2018ZX10305409-004-001]
- Youth innovation promotion association of CAS [2019328]
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats(1-4). Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans(5-7). Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.
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