期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 20, 页码 3446-3451出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1709190
关键词
Epigenetic manipulation; fungal endophytes; SAHA; silent genes
资金
- Natural Science Foundation of Zhejiang Province [LY17B020011]
Chemical investigation of the culture broth of the plant endophyte Penicillium sp. HS-11 in a modified Martin's medium supplemented with subemylanilide hydroxamic acid (SAHA) led to the discovery and identification of two induced products, including a new compound 4-epipenicillone B. Detailed spectroscopic and quantum chemistry analyses were conducted to elucidate the structure of 4-epipenicillone B, enriching the diversity of fungal natural products. The cytotoxic activity of 4-epipenicillone B was also evaluated in this study.
Chemical investigation into the culture broth of the plant endophyte Penicillium sp. HS-11 in the modified Martin's medium supplemented with subemylanilide hydroxamic acid (SAHA), a well-known histone deacetylase (HDACs) inhibitor, led to the isolation and identification of two induced products 4-epipenicillone B (1) and (R)-(+)-chrysogine (2). 4-epipenicillone B (1) was obtained as a new compound whose structure was elucidated by comprehensive spectroscopic methods including 1 D/2D NMR, HRESMS, and quantum chemistry calculations including DFT GIAO C-13 NMR and ECD calculation. Acquisition of 4-epipenicillone B (1) enriched the chemical diversities of fungal natural products possessing a tricyclo [5.3.1.0(3,8)] undecane skeleton. The cytotoxic activity of 1 was also evaluated.
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