期刊
NANOMEDICINE
卷 14, 期 23, 页码 3035-3055出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2019-0253
关键词
anisotropic nanoparticles; biological corona; distribution; elimination; gold nanoparticles; PEG; polyethylene glycol; protein corona; surface charge; toxicity
资金
- National Key Basic Research Program (973 project) [2015CB931802, 2010CB933901]
- 863 Project of China [2014AA020700]
- Spanish MINECO [BIO2017-84246-C2-1-R]
- DGA
- Fondos Feder (Bionanosurf) [E15 17R]
- China Scholarship Council [2015GSXYE19]
- Spanish Ministerio de Educacion, Cultura y Deportes [FPU014/06249]
- Ramon y Cajal subprogram [RYC-2014-15512]
Aim: To study the difference in biodistribution of gold nanoprisms (NPr) and nanorods (NR), PEGylated to ensure colloidal stability. Materials & methods: Surface changes were studied for nanoparticles in different media, while the biodistribution was quantified and imaged in vivo. Results: Upon interaction with the mouse serum, NR showed more abrupt changes in surface properties than NPr. In the in vivo tests, while NPr accumulated similarly in the spleen and liver, NR showed much higher gold presence in the spleen than in liver; together with some accumulation in kidneys, which was nonexistent in NPr. NPr were cleared from the tissues 2 months after administration, while NR were more persistent. Conclusion: The results suggest that the differential biodistribution is caused by size-/shape-dependent interactions with the serum.
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