期刊
NANO RESEARCH
卷 13, 期 3, 页码 653-660出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-020-2668-1
关键词
nanozyme; metal-organic frameworks; gold nanoparticles; near-infrared light; reactive oxygen species
类别
资金
- National Natural Science Foundation of China [21874066, 81601632, 61804076]
- Natural Science Foundation of Jiangsu Province [BK20160616, BK20180700]
- Fundamental Research Funds for Central Universities
- Shuangchuang Program of Jiangsu Province
- Thousand Talents Program for Young Researchers
We report gold nanoparticles (AuNPs) doped iron-based metal-organic frameworks (GIM) which displays near-infrared light (NIR)-enhanced cascade nanozyme against hypoxic tumors. Due to the strong protein adsorption-induced surface passivation, AuNPs suffer from the loss of glucose oxidase (GOx) activity. However, GIM could protect the GOx-like activity of AuNPs with the satisfactory shield capability. In addition, GIM exhibited excellent photothermal conversion ability and unique NIR light-enhanced GOx-like activity, which could efficiently increase the endogenous H2O2 production. Meanwhile, as the produced H2O2 is converted by GIM into O-2 and highly toxic OH. Thus, GIM-catalyzed cascade reactions with NIR light irradiation not only offer the O-2 but also promote the reactive oxygen species (ROS) generation at tumor sites. The produced O-2 could be further applied to AuNPs catalytic oxidation of glucose and relieve hypoxic condition of tumor microenvironment (TME). As a proof-of-concept study, GIM demonstrates the admirable tumor ablation under NIR irradiation in vivo.
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