期刊
NANO RESEARCH
卷 13, 期 3, 页码 709-718出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-020-2680-5
关键词
crystal phase structure; MnO2; oxidase mimics; surface hydroxyls; 3; 3'; 5; 5'-tetramethylbenzidine (TMB); glutathione
类别
资金
- National Key R&D Program of China [2016YFA0202900]
- China Postdoctoral Science Foundation [2018M642021]
- National Natural Science Foundation of China [21677095]
- Minhang District Science and Technology Project of Shanghai [2019MH-MS02]
The crystal structures would directly affect the physical and chemical properties of the surface of the material, and would thus influence the catalytic activity of the material. alpha-MnO2, beta-MnO2 and gamma-MnO2 nanorods with the same morphology yet different crystal structures were prepared and tested as oxidase mimics using 3,3',5,5'-tetramethylbenzidine (TMB) as the substrate. beta-MnO2 that exhibited the highest activity had a catalytic constant of 83.75 mu mol center dot m(-2)center dot s(-1), 2.7 and 19.0 times of those of alpha-MnO2 and gamma-MnO2 (30.91 and 4.41 mu mol center dot m(-2)center dot s(-1)), respectively. The characterization results showed that there were more surface hydroxyls as well as more Mn4+ on the surface of the beta-MnO2 nanorods. The surface hydroxyls were conducive to the oxidation reaction, while Mn4+ was conducive to the regeneration of surface hydroxyls. The synergistic effect of the two factors significantly improved the activity of beta-MnO2 oxidase mimic. Using beta-MnO2, a beta-MnO2-TMB-GSH system was established to detect the content of glutathione (GSH) rapidly and sensitively by colorimetry. This method had a wide detection range (0.11-45 mu M) and a low detection limit (0.1 mu M), and had been successfully applied to GSH quantification in human serum samples.
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