期刊
NANO RESEARCH
卷 13, 期 1, 页码 160-172出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-019-2591-5
关键词
Au/Pt star; GSH-responsive; GOx; peroxidase; sequential nanocatalyst; cancer starving-like therapy; enzyme oxidative therapy; photo-thermal therapy & photodynamic therapy (PTT&PDT)
类别
资金
- National Basic Research Program of China [2017YFA0205301, 2015CB931802]
- National Natural Scientific Foundation of China [81903169, 81803094, 81602184, 81822024, 81571729]
- Shanghai Municipal Commission of Economy and Information Technology Fund [XC-ZXSJ-02-2016-05]
- Medical Engineering Cross Project of Shanghai Jiao Tong university [YG2016ZD10, YG2017Z D05]
- Project of Thousand Youth Talents from China
- National Key Research and Development Program of China [2017YFC1200904]
- Shanghai Sailing Program [19YF1422300]
- Startup Fund for Yongman Research at SJTU [18X100040044]
- Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument [15DZ2252000]
Distinctively different metabolism between tumor cells and normal cells endows tumor tissues unique microenvironment. In this regard, we have successfully prepared a sequential catalytic platform based on Au/Pt star for tumor theragnostic. The multifunctional probes consisted of a gold/platinum star-shaped core (Au/Pt star) conjugated with a GSH-sensitive disulfide bond (S-S), a targeting ligand (rHSA-FA), a near-infrared fluorophore (IR780) and glucose oxidase (GOx). When systemically administered in a xenografted murine model, the probes specifically targeted the tumor sites. As the disulfide linker was cleaved by intracellular GSH, the IR780 molecules could be released for photo-thermal therapy & photodynamic therapy (PTT&PDT) and imaging. Subsequently, the Pt nanolayer of the Au/Pt star and the GOx formed a sequential catalytic system: GOx effectively catalyzed intracellular glucose by consuming oxygen to generate H2O2 and enhance the local acidity, and the Pt layer exhibited peroxidase-like property to catalyze H2O2 producing toxic center dot OH for tumor oxidative damage. Here we demonstrated that our probes simultaneously possessed a GSH-sensitive release, real-time imaging ability, and synergetic cancer starving-like therapy/enzyme oxidative therapy/PTT/PDT features, which provides a potential strategy for effective tumor theragnostic.
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