期刊
NANO LETTERS
卷 20, 期 2, 页码 1447-1454出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b05218
关键词
black phosphorus nanosheets; antioxidative agent; reactive oxygen species; acute kidney injury; kidney targeting drug delivery
类别
资金
- National Natural Science Foundation of China [21675167, 21905262]
- Youth Innovation Promotion Association of CAS [2012205]
- Shanghai Pujiang Program [19PJ1404700]
Black phosphorus nanosheets (BPNSs) have been actively employed as nanomedicine agents for photothermal and photodynamic therapy by virtue of their unique optical properties. However, their chemical reactivity as a competent biomaterial has not been fully explored yet. Here, we report on the use of BPNSs as reactive oxygen species (ROS) scavengers to cure acute kidney injury (AKI) in mice. Importantly, in vivo analysis in mice revealed that BPNSs were preferably accumulated in kidney. We found that BPNSs alleviated oxidative-pressure-induced cellular apoptosis. In a ROS-triggered acute kidney injury (AKI) model, BPNSs effectively consumed ROS in kidney, demonstrating high efficacy for curing AKI. BPNSs also exhibited excellent biocompatibility and biodegradability, making them promising candidates for therapeutic treatment of AKI and other renal diseases.
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