期刊
MOVEMENT DISORDERS
卷 35, 期 6, 页码 1062-1066出版社
WILEY
DOI: 10.1002/mds.28015
关键词
alpha-synuclein; cerebrospinal fluid; cytokine; Parkinson's disease; tau
资金
- Rosetrees Trust [M369-F1]
- Addenbrooke's Charitable Trust [RG77199, PF15/CWG]
- NIHR Cambridge Biomedical Research Centre Dementia and Neurodegeneration Theme [146281]
- Transeuro EU FP7 grant [242003]
- Wellcome Trust Clinical Research Career Development Fellowship [214571/Z/18/Z]
- Wellcome Trust-MRC Cambridge Stem Cell Institute [203151/Z/16/Z]
- Research Councils United Kingdom/United Kingdom Research Innovation Fellowship - Medical Research Council [MR/R007446/1]
- Cambridge Centre for Parkinson-Plus
- Wellcome Trust [214571/Z/18/Z, 203151/Z/16/Z] Funding Source: Wellcome Trust
- MRC [MR/R007446/1, MC_PC_17230] Funding Source: UKRI
Introduction Immune markers are altered in Parkinson's disease (PD), but relationships between cerebrospinal fluid (CSF) and plasma cytokines and associations with neurodegeneration-associated proteins remain unclear. Methods CSF and plasma samples and demographic/clinical measures were obtained from 35 PD patients. CSF samples were analyzed for cytokines (together with plasma) and for alpha-synuclein, amyloid beta(1-42) peptide, total tau, and phospho(Thr231)-tau. Results There were no CSF-plasma cytokine correlations. Interleukin (IL)-8 was higher and interferon-gamma, IL-10, and tumor necrosis factor-alpha were lower in CSF versus plasma. In CSF, total tau correlated positively with IL-8 and IL-1 beta, whereas alpha-synuclein correlated positively with amyloid beta(1-42) and negatively with semantic fluency (a known marker of PD dementia risk). Discussion CSF and peripheral cytokine profiles in PD are not closely related. Associations between CSF IL-8 and IL-1 beta and tau suggest that CSF inflammatory changes may relate to tau pathology within PD. CSF alpha-synuclein/amyloid beta may reflect the risk of developing PD dementia. (c) 2020 The Authors.Movement Disorderspublished by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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