期刊
MOLECULES
卷 25, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/molecules25040978
关键词
GAG; hydrogels; hybrid systems; biomaterials; polysaccharides; proteins; self-assembly peptides; GAG-mimetics
资金
- FEDER-Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020-Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020
- Portuguese funds through FCT-Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Ensino Superior in the framework of Project ANGIONICHE [POCI-01-0145-FEDER-028744, PTDC/BTMMAT/28744/2017]
- FCT [SFRH/BD/129855/2017, POCI-01-0145-FEDER-032431, PTDC/CTM-COM/32431/2017]
- FEDER
- Agencia para o Desenvolvimento e Coesao
- Ministerio de Hacienda, Direccion General de Fondos Europeos for Interreg V-A Spain-Portugal (POCTEP) 2014-2020
- FEDER [0245_IBEROS_1_E]
- [IF/00296/2015]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/129855/2017, PTDC/CTM-COM/32431/2017] Funding Source: FCT
Glycosaminoglycans (GAG) are long, linear polysaccharides that display a wide range of relevant biological roles. Particularly, in the extracellular matrix (ECM) GAG specifically interact with other biological molecules, such as growth factors, protecting them from proteolysis or inhibiting factors. Additionally, ECM GAG are partially responsible for the mechanical stability of tissues due to their capacity to retain high amounts of water, enabling hydration of the ECM and rendering it resistant to compressive forces. In this review, the use of GAG for developing hydrogel networks with improved biological activity and/or mechanical properties is discussed. Greater focus is given to strategies involving the production of hydrogels that are composed of GAG alone or in combination with other materials. Additionally, approaches used to introduce GAG-inspired features in biomaterials of different sources will also be presented.
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