期刊
MOLECULES
卷 24, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/molecules24244522
关键词
algicidal bacteria; questiomycins; phenoxazinone antibiotics; Alteromonas; Chattonella antiqua; harmful algal bloom; red tide
资金
- JSPS KAKENHI [15H05629]
- MEXT KAKENHI [25108701]
- Grants-in-Aid for Scientific Research [15H05629, 25108701] Funding Source: KAKEN
Questiomycin A (1) along with three new compounds, questiomycins C-E (2-4), were isolated from culture of Alteromonas sp. D, an algicidal marine bacterium, guided by algal lethality assay using the raphidophyte, Chattonella antiqua, one of the causative organisms of harmful algal bloom. The structures of 1-4 were assigned on the basis of their spectrometric and spectroscopic data. Compounds 1 to 4 exhibited algicidal activity against C. antiqua with LC50 values ranging from 0.18 to 6.37 mu M. Co-cultivation experiment revealed that 1 was produced only when the microalgae and the bacterium are in close contact, suggesting that some interactions between them trigger the biosynthesis of questiomycins. These results suggested that the algicidal bacteria such as Alteromonas sp. D can control microalgae chemically in marine ecosystem.
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