期刊
MOLECULES
卷 25, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules25030684
关键词
cannabinoids; cannabilactones; CB2 selective ligands; Suzuki cross-coupling
资金
- National Institutes of Health [DA009158, DA045020, DA041307-01]
A new approach to synthesize cannabilactones using Suzuki cross-coupling reaction followed by one-step demethylation-cyclization is presented. The two key cannabilactone prototypes AM1710 and AM1714 were obtained selectively in high overall yields and in a lesser number of synthetic steps when compared to our earlier synthesis. The new approach expedited the synthesis of cannabilactone analogs with structural modifications at the four potential pharmacophoric regions.
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