期刊
MOLECULES
卷 25, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/molecules25020332
关键词
Oridonin; structural modification; formulations; solubility; bioavailability; biological activity
资金
- Shandong Provincial Natural Science Foundation, China [BS2014YY047]
- Medical and Health Science and Technology Development Plan of Shandong Province, China [2018WS202]
Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据