期刊
MOLECULES
卷 25, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/molecules25010099
关键词
Rutaceae; Clausena anisum-olens; carbazole alkaloids; anti-HIV
资金
- National Natural Science Foundation of China [81960629, 21662040, 21462048, 21162038, 21262040]
- China Scholarship Council (CSC) [201508535020, 2007PY01-23]
- NIH [AI033066]
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1(NL4-3) Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 mu g/mL and SI of 7.1.
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