期刊
MOLECULES
卷 24, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/molecules24244489
关键词
Aster koraiensis; triterpene saponin; autophagy; natural products
资金
- Korea Institute of Science and Technology Program [2Z05620]
- National Research Foundation of the Ministry of Science, Information and Communications Technology (ICT) & Future Planning of Republic of Korea [NRF-2015M3A9A5030735]
- Bio-Synergy Research Project [NRF-2012M3A9C4048793]
- National Research Foundation of Korea [2Z05620] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Autophagy is an important self-degradative mechanism that plays a key role in treating neurodegeneration diseases. This research aimed at discovering bioactive compounds from Aster koraiensis. A new triterpene saponin, astersaponin I (1), was isolated from the EtOH extract of A. koraiensis. The structure of 1 was characterized by spectroscopic methods, ECD calculation, and acid hydrolysis. The biochemical analysis showed that compound 1 significantly increased the expression of microtubule-associated protein 1A/1B light chain 3B (LC3-II) expression in SH-SY5Y cells, which indicates the induction of autophagy. Thus, further study may be needed to clarify whether compound 1 exerts beneficial effects on neurodegeneration diseases like Parkinson's disease through autophagy induction.
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