期刊
MOLECULAR IMMUNOLOGY
卷 117, 期 -, 页码 180-188出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2019.11.011
关键词
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资金
- National Institutes of Health [RO1-AI132404]
- Canadian Institutes of Health Research [PJT-152903, PJT-162212]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2016-04713]
- Canada Foundation for Innovation
- Fonds de Recherche du Quebec -Sante
IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of innate and adaptive immunity. Besides its established role in controlling homeostatic proliferation and survival of memory CD8(+) T cells and natural killer cells, recent findings demonstrate that inflammatory IL-15 can also stimulate a variety of effector functions, such as enhanced cytotoxicity, entry into the cell cycle, and trafficking into non-lymphoid tissues. Here, we discuss how IL-15 is critical in regulating many functions of memory CD8(+) T cells and how these processes act collectively to ensure optimal protective cellular immunity against re-infections.
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