期刊
MOLECULAR DIVERSITY
卷 25, 期 1, 页码 205-221出版社
SPRINGER
DOI: 10.1007/s11030-020-10048-8
关键词
Pimprinine; 1,3,4-oxadiazole-5-thioether; Diversity-oriented synthesis; Antifungal activity; SAR
类别
资金
- National Natural Science Foundation of China [21602110]
- National Key R&D Program of China [2018YFC1602804]
- Jiangsu Provincial Science Foundation for Youths [BK20160734]
- Fundamental Research Funds and for the Central Universities [KYTZ201604, KYLH201908]
Through diversity-oriented synthesis strategy, two series of novel pimprinine derivatives containing 1,3,4-oxadiazole-5-thioether moieties were efficiently synthesized under optimized conditions. Biological assays showed potential activity in designed derivatives, with one compound demonstrating strong antifungal activity. Further structural optimization is ongoing to discover synthetic analogues with improved antifungal activity.
Based on the strategy of diversity-oriented synthesis and the structures of natural product pimprinine and streptochlorin, two series of novel pimprinine derivatives containing 1,3,4-oxadiazole-5-thioether moieties were efficiently synthesized under the optimized reaction conditions. Biological assays conducted at Syngenta showed the designed derivatives displayed an altered pattern of biological activity, of which 5h was identified as the most promising compound with strong activity against Pythium dissimile and also a broad antifungal spectrum in primary screening. Further structural optimization of pimprinine and streptochlorin derivatives is well under way, aiming to discover synthetic analogues with improved antifungal activity. Graphic abstract Two series of novel pimprinine derivatives containing 1,3,4-oxadiazole-5-thioether moieties were efficiently synthesized through diversity-oriented synthesis strategy under the optimized conditions. Biological assays showed the designed derivatives exhibited potential activity. [GRAPHICS] .
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