期刊
MOLECULAR CANCER
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12943-019-1110-3
关键词
FOXP proteins; Molecular networks; Noncoding RNAs; Cellular immunotherapy; Clinical implications and cancer progression
资金
- Korea Science and Engineering Foundation (KOSEF) - Korea government (MEST) [2017R1A2A1A17069297]
Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression.
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