期刊
MOLECULAR BIOLOGY
卷 54, 期 1, 页码 119-127出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0026893320010082
关键词
B. subtilis 20; International Space Station; DNA-damaging factors; NHEJ operon; oxidative stress
资金
- Russian Science Foundation [17-74-30030]
- Fundamental Research Program for the State Academies of Sciences [AAAA-A19-119010590015-8]
- Russian Academy of Sciences Programs [01201373016, 01201367566]
Bacillus subtilis bacteria play an important role in veterinary medicine, medicine, and biotechnology, and the permanently growing demand for biotechnological products fuels the improvement of the properties of biotechnological strains. B. subtilis strains with improved characteristics may be obtained by rational design and the directed evolution technologies, or be found among newly described strains. In the course of the long-term microbiome composition studies in the Russian segment of the International Space Station, the B. subtilis 20 strain was isolated, this strain shows the capacity for rapid growth and considerable biomass accumulation, as well as increased resistance to acidification of the environment in comparison to the terrestrial B. subtilis 168 strain. What is more, B. subtilis 20 is hyperresistant to the DNA and protein damaging factors that are linked to the overexpression of the genes controlling DNA repair, hydrogen sulfide production, and reactive oxygen species neutralization. The described properties of B. subtilis 20 are indicative of its considerable potential as a promising producer of biologically active compounds.
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