期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 501, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2019.110652
关键词
Corticotropin-releasing hormone; Paraventricular nucleus; Circadian; Ultradian; Rhythm; Pituitary; Adrenal; Glucocorticoid receptor
资金
- Royal Society Marsden Fund
- Health Research Council of New Zealand
Oscillations are a fundamental feature of neural and endocrine systems. The hypothalamic-pituitary-adrenal (HPA) axis dynamically controls corticosteroid secretion in basal conditions and in response to stress. Across the 24-h day, HPA axis activity oscillates with both an ultradian and circadian rhythm. These rhythms have been shown to be important for regulating metabolism, inflammation, mood, cognition and stress responsiveness. Here we will discuss the neural and endocrine mechanisms driving these rhythms, the physiological importance of these rhythms and health consequences when they are disrupted.
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