期刊
MICROCHIMICA ACTA
卷 187, 期 1, 页码 -出版社
SPRINGER WIEN
DOI: 10.1007/s00604-019-4020-6
关键词
Indicator displacement assay; Turn on-off fluorescence; Biological fluids
资金
- National Natural Science Foundation of China [31700876, 31700862]
- Natural Science Foundation of Shanxi Province [201601D021106]
- Basic Research Program of Shanxi Normal University [ZR1602]
A turn on-off fluorometric assay for clioquinol (CQ) is described here. It is based on modulation of the fluorescence of sulfur quantum dots (SQDs; best measured at excitation/emission wavelengths of 360/426 nm) by using the Zn2+-CQ affinity pair. Although the fluorescence enhancement effect of Zn2+ on SQDs was not obvious, a good quenching modulation effect was observed in the presence of CQ. This resulted in a linear analytical range that is increased by two orders of magnitude (from 0.024 mu M to 0.24 mu M, and 0.62 mu M to 30 mu M), with a detection limit (3 s) of 0.015 mu M. The selectivity of the method is also improved.
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