期刊
MICROBIAL PATHOGENESIS
卷 140, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2019.103950
关键词
Type I interferon; Stimulator of interferon genes; Cyclic di-AMP; Innate immune response; Chlanrydiae
资金
- National Natural Science Foundation of China [31470277, 81772210]
- Construct Program of the Key Discipline in Hunan Province [2011-76]
- Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control [2014-5]
- Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-8]
- Hunan Provincial Innovation Foundation for Postgraduate [CX20190715]
The past decades have witnessed significant progress in discovery and characterize cytosolic DNA sensing and signaling, especially the understanding of the stimulator of interferon genes (STING). This pathway to foreign nucleic acids enables the initiation of robust anti-pathogenic responses to protect the host, and provides a new understanding for therapeutic intervention in a growing infectious disease, including chlamydial infection. Chlamydiae are obligate intracellular pathogenic bacterium causing widespread human diseases such as sexually transmitted infections and respiratory tract infections. Previous studies have shown that IFN production and autophagy are well recognized as being two critical processes induced by STING, and these two processes were also activated during chlamydial infection. In this review, we summarize the important characteristics of the STING activation pathway and recent snapshots about the role of STING in chlamydial infection. Studying the role of STING in chlamydial infection could provide valuable information to further understand the pathogenesis and treatment of chlamydial infection.
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