期刊
MICROBIAL DRUG RESISTANCE
卷 26, 期 11, 页码 1307-1320出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2019.0325
关键词
antimicrobial resistance; microbiome; autism; metagenome
资金
- Russian Science Foundation [17-15-01488]
- state Genetic technologies in biology, medicine, agricultural, and environmental activities'' [0112-2019-0002 2019]
- Russian Science Foundation [17-15-01488] Funding Source: Russian Science Foundation
The gut microbiota (GM), which contains thousands of bacterial species, is a reservoir of antibiotic resistance genes (ARGs) called resistome. Early life exposure to antibiotics alters significantly the composition and function of the gut microbiota of children, which may trigger symptoms of autism spectrum disorder (ASD). This is because the GM plays an important role in the bidirectional communication between the gut and the brain and influences the brain normal functioning through multiple pathways. The goal of this article is to study the distribution of ARGs in the GM of 3- to 5-year-old healthy children and children with ASD living in Moscow, Russia. The metagenomic analysis of samples from both groups revealed differences in the signatures between them. The signatures consisted of the bacterial genera and aminoglycoside, beta-lactam, macrolide, and tetracycline resistance genes that they harbored. Our results show an increase in ARGs in the resistome of the GM of children with ASD. These findings emphasize the negative influence of early-life antibiotic therapy. We found three ARGs, aac(6 ')-aph(2 ''), cepA-49, and tet(40), which could serve as markers of ASD. The additional functions carried out by the enzymes, encoded by these genes, are being discussed.
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