Greater Lower Limb Fatigability in People with Prediabetes than Controls

Introduction The study purpose was to compare perceived fatigability and performance fatigability after high-velocity contractions with knee extensor muscles between people with prediabetes, people with type 2 diabetes (T2D), and controls without diabetes matched for age, body mass index, and physical activity. Methods Twenty people with prediabetes (11 men, 9 women: 63.1 +/- 6.0 yr, 26.9 +/- 4.2 kg center dot m(-2), 8030 +/- 3110 steps per day), 39 with T2D (23 men, 16 women: 61.2 +/- 8.5 yr, 29.4 +/- 6.4 kg center dot m(-2), 8440 +/- 4220 steps per day), and 27 controls (13 men, 14 women: 58.1 +/- 9.4 yr, 27.3 +/- 4.3 kg center dot m(-2), 8400 +/- 3000 steps per day) completed the Fatigue Impact Scale as a measure of perceived fatigability and a fatigue protocol including 120 maximal-effort, high-velocity concentric contractions (MVCC; 1 contraction/3 s) with the knee extensors using a submaximal load (30% maximum) to quantify performance fatigability. Electrical stimulation was used to assess voluntary activation and contractile function of the knee extensor muscles before and after the fatigue protocol. Results Fatigue Impact Scale scores were not different between people with prediabetes, people with T2D, and controls (12.5 +/- 15.1, 18.3 +/- 22.7, and 12.6 +/- 18.6, respectively; P = 0.517). However, people with prediabetes had greater reductions in MVCC power during the fatigue protocol than did controls (31.8% +/- 22.6% vs 22.1% +/- 21.1%, P < 0.001), and both groups had lesser reductions than the T2D group (44.8% +/- 21.9%, P < 0.001). Similarly, the prediabetes group had larger reductions in electrically evoked twitch amplitude than the control group (32.5% +/- 24.9% vs 21.3% +/- 33.0%, P < 0.001), but lesser reductions than those with T2D (44.0% +/- 23.4%, P < 0.001). For all three groups, a greater decline in MVCC power was associated with larger reductions of twitch amplitude (r(2) = 0.350, P < 0.001). Conclusion People with prediabetes have greater performance fatigability of the knee extensors due to contractile mechanisms compared with controls, although less performance fatigability than that of people with T2D.