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ANTIVIRAL RESEARCH (2010)
Synthesis of a novel tricyclic 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system and CXCR4 antagonists with potent activity against HIV-1
John G. Catalano et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Small Molecular Compounds that Inhibit Hepatitis C Virus Replication Through Destabilizing Heat Shock Cognate 70 Messenger RNA
Zong-Gen Peng et al.
HEPATOLOGY (2010)
Small Molecular Compounds Inhibit HIV-1 Replication through Specifically Stabilizing APOBEC3G
Shan Cen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Safety and efficacy of viramidine versus ribavirin in ViSER2: Randomized, double-blind study in therapy-naive hepatitis C patients
Patrick Marcellin et al.
JOURNAL OF HEPATOLOGY (2010)
Heat Shock Protein 90: Inhibitors in Clinical Trials
Marco A. Biamonte et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
ATPases as Drug Targets: Insights from Heat Shock Proteins 70 and 90
Andrew J. Massey
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Antagonism of CD317 Restriction of Human Immunodeficiency Virus Type 1 (HIV-1) Particle Release and Depletion of CD317 Are Separable Activities of HIV-1 Vpu
Christine Goffinet et al.
JOURNAL OF VIROLOGY (2010)
Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin
Sheli R. Radoshitzky et al.
JOURNAL OF VIROLOGY (2010)
Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity
Chu-Biao Xue et al.
ACS MEDICINAL CHEMISTRY LETTERS (2010)
Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication
Xiaoling Liu et al.
CELLULAR MICROBIOLOGY (2009)
Plerixafor In Patients with Non-Hodgkin's Lymphoma or Multiple Myeloma
Antona J. Wagstaff
DRUGS (2009)
The Anti-Hepatitis C Agent Nitazoxanide Induces Phosphorylation of Eukaryotic Initiation Factor 2α Via Protein Kinase Activated by Double-Stranded RNA Activation
Menashe Elazar et al.
GASTROENTEROLOGY (2009)
Merimepodib, Pegylated Interferon, and Ribavirin in Genotype 1 Chronic Hepatitis C Pegylated Interferon and Ribavirin Nonresponders
Vinod K. Rustgi et al.
HEPATOLOGY (2009)
A Phase III Study of the Safety and Efficacy of Viramidine Versus Ribavirin in Treatment-Naive Patients with Chronic Hepatitis C: ViSER1 Results
Yves Benhamou et al.
HEPATOLOGY (2009)
The Heat Shock Cognate Protein 70 Is Associated with Hepatitis C Virus Particles and Modulates Virus Infectivity
Romain Parent et al.
HEPATOLOGY (2009)
Broad-Spectrum Inhibition of Retroviral and Filoviral Particle Release by Tetherin
Nolwenn Jouvenet et al.
JOURNAL OF VIROLOGY (2009)
Molecular Mechanism of BST2/Tetherin Downregulation by K5/MIR2 of Kaposi's Sarcoma-Associated Herpesvirus
Mandana Mansouri et al.
JOURNAL OF VIROLOGY (2009)
Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein
Rachel L. Kaletsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity
Eva-K Pauli et al.
RETROVIROLOGY (2009)
Target Cell Cyclophilins Facilitate Human Papillomavirus Type 16 Infection
Malgorzata Bienkowska-Haba et al.
PLOS PATHOGENS (2009)
Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
Brent E. Korba et al.
ANTIVIRAL RESEARCH (2008)
Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid-Glutamic Acid-Alanine-Aspartic Acid Box Polypeptide 3
Giovanni Maga et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Small-molecule inhibition of HIV-1 Vif
Robin Nathans et al.
NATURE BIOTECHNOLOGY (2008)
Hsp90 inhibitors reduce influenza virus replication in cell culture
Geoffrey Chase et al.
VIROLOGY (2008)
Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication
Shuhei Taguwa et al.
JOURNAL OF VIROLOGY (2008)
DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication
Yasuo Ariumi et al.
JOURNAL OF VIROLOGY (2007)
Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP
Martin Hogbom et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects
Nimalie D. Stone et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Antiviral activity and RNA polyinerase degradation following Hsp90 inhibition in a range of negative strand viruses
John H. Connor et al.
VIROLOGY (2007)
Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits
Tadasuke Naito et al.
JOURNAL OF VIROLOGY (2007)
Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance
Ron Geller et al.
GENES & DEVELOPMENT (2007)
IMPDH as a biological probe for RNA antiviral drug discovery: Synthesis, enzymology, molecular docking, and antiviral activity of new ribonucleosides with surrogate bases
Vasu Nair et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2007)
NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon
Sue Ma et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Inhibition of hepatitis B virus replication by APOBEC3G in vitro and in vivo
Yan-Chang Lei et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2006)
Different anti-HCV profiles of statins and their potential for combination therapy with interferon
Masanori Ikeda et al.
HEPATOLOGY (2006)
Effects of bezafibrate in patients with chronic hepatitis C virus infection: combination with interferon and ribavirin
N. Fujita et al.
JOURNAL OF VIRAL HEPATITIS (2006)
Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent anti-HIV-1 activity
S Imamura et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex
K Shirakawa et al.
VIROLOGY (2006)
The geographic spread of the CCR5 Δ32 HIV-resistance allele
J Novembre et al.
PLOS BIOLOGY (2005)
Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
G Fätkenheuer et al.
NATURE MEDICINE (2005)
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor
S Hatse et al.
BIOCHEMICAL PHARMACOLOGY (2005)
Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone Hsp90 for proper localization to the nucleus
AD Burch et al.
JOURNAL OF VIROLOGY (2005)
Pharmacokinetics and short-term safety of 873140, a novel CCR5 antagonist, in healthy adult subjects
KK Adkison et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase
P Leyssen et al.
JOURNAL OF VIROLOGY (2005)
Inhibition of hepatitis B virus replication by APOBEC3G
P Turelli et al.
SCIENCE (2004)
Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro
YH Li et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
Specific inhibition of hepatitis C virus replication by cyclosporin A
M Nakagawa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A
C Luo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist
K Princen et al.
JOURNAL OF VIROLOGY (2004)
Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function
VSRK Yedavalli et al.
CELL (2004)
Piperazine-based CCR5 antagonists as HIV-1 inhibitors.: IV.: Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-[4-{2-methoxy-1(R)-4-(trifluoromethyl)-phenyl}ethyl-3(S)-methyl-1-piperazinyl]-4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist
JR Tagat et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome
Q Yu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication
MJ Bouchard et al.
JOURNAL OF VIROLOGY (2003)
The bicyclam AMD3 100 story
E De Clercq
NATURE REVIEWS DRUG DISCOVERY (2003)
Hypermutation of HIV-1 DNA in the absence of the Vif protein
D Lecossier et al.
SCIENCE (2003)
Sanglifehrin-cyclophilin interaction: Degradation work, synthetic macrocyclic analogues, X-ray crystal structure, and binding data
R Sedrani et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Molecular chaperone GRP78/BiP interacts with the large surface protein of hepatitis B virus in vitro and in vivo
DY Cho et al.
JOURNAL OF VIROLOGY (2003)
Combined interferon alpha 2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial
K Inoue et al.
JOURNAL OF GASTROENTEROLOGY (2003)
Exploring the stereochemistry of CXCR4-peptide recognition and inhibiting HIV-1 entry with D-peptides derived from chemokines
NM Zhou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A
DA Bosco et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Heat shock cognate protein 70 is involved in rotavirus cell entry
CA Guerrero et al.
JOURNAL OF VIROLOGY (2002)
Antiviral activity and mode of action studies of ribavirin and mycophenolic acid against orthopoxviruses in vitro
DF Smee et al.
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY (2001)
Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action
G Zenke et al.
JOURNAL OF IMMUNOLOGY (2001)
RNA virus error catastrophe: Direct molecular test by using ribavirin
S Crotty et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen
S Crotty et al.
NATURE MEDICINE (2000)
Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon
W Markland et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)
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