期刊
MEDICAL PHYSICS
卷 47, 期 2, 页码 790-811出版社
WILEY
DOI: 10.1002/mp.13943
关键词
attenuation estimation; lung; medical imaging; magnetic resonance imaging; positron emission tomography
资金
- Siemens Healthineers
- UCL IMPACT scheme
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- EPSRC [EP/K005278/1] Funding Source: UKRI
Positron emission tomography/magnetic resonance imaging (PET/MRI) potentially offers several advantages over positron emission tomography/computed tomography (PET/CT), for example, no CT radiation dose and soft tissue images from MR acquired at the same time as the PET. However, obtaining accurate linear attenuation correction (LAC) factors for the lung remains difficult in PET/MRI. LACs depend on electron density and in the lung, these vary significantly both within an individual and from person to person. Current commercial practice is to use a single-valued population-based lung LAC, and better estimation is needed to improve quantification. Given the under-appreciation of lung attenuation estimation as an issue, the inaccuracy of PET quantification due to the use of single-valued lung LACs, the unique challenges of lung estimation, and the emerging status of PET/MRI scanners in lung disease, a review is timely. This paper highlights past and present methods, categorizing them into segmentation, atlas/mapping, and emission-based schemes. Potential strategies for future developments are also presented.
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