期刊
MEDICAL ENGINEERING & PHYSICS
卷 77, 期 -, 页码 19-30出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2020.01.004
关键词
Biphasic fluid; Cell clusters; Encapsulation; Smoothed Particle Hydrodynamics; Surface tension
资金
- Cariplo Foundation [2011-2241, 2015-1044]
- Diabetes Research Institute Foundation
- Juvenile Diabetes Research Foundation [5-CDA-2016-171-S-B, JDRF 3-SRA-2017-347-M]
- National Institute of Health [DK109929]
The paper discusses a Smoothed Particle Hydrodynamics (SPH) model for the analysis of the multiphase flow occurring in an experimental microfluidic device for conformal coating of pancreatic islets with a biocompatible and permeable polymer. The proposed numerical model, based on a weakly-compressible SPH approach, accurately mimics the encapsulation process while assuring phase conservation, thus overcoming potential limitations of grid-based models. The proposed SPH model is a triphasic multi-phase model that allows one: (i) to reproduce the physics of islet conformal coating, including the effects of surface tension at the interface of the involved fluids and of the islet diameter; and (ii) to evaluate how modulation of process parameters influences the fluid dynamics within the microfluidic device and the resulting coating characteristics. This model can represent a valuable, time- and cost-effective tool for the definition of optimized encapsulation conditions through in silico screening of novel combinations of conformal coating parameters, including polymeric coating blends, size range of insulin-secreting cell clusters, utilized chemical reagents, device geometry and scale. (C) 2020 IPEM. Published by Elsevier Ltd. All rights reserved.
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