期刊
MEDICAL ENGINEERING & PHYSICS
卷 77, 期 -, 页码 118-124出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2019.10.020
关键词
Pulsatile pump; Hemodynamics; Blood flow; Servo motor
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2018R1D1A1A02043249]
- Kangwon National University [D1001679-0101]
In-vitro cardiovascular experiments provide an effective means for characterizing structural or hemodynamic features of medical devices before they are tested on animals or used in clinical practice. Invitro experiments simulate complicated cardiovascular systems with blood pumps, vessels and valves, but without human or animal subjects. Therefore, such experiments are free from ethical issues and present large cost savings in comparison to in-vivo experiments. In this study, we aimed to design a fully programmable pulsatile flow pump that can consistently and accurately reproduce a wide range of physiological flow waveforms without costly transient flowmeter in the system. An iterative control algorithm (ICA) was used to minimize the differences between the desired and produced flow waveforms. Our results confirm that the developed pulsatile pump can replicate flow waveforms accurately, with root mean square errors (RMSEs) of 0.64 L/min and 0.52 mL for the flow rate and stroke volume, respectively. (C) 2019 IPEM. Published by Elsevier Ltd. All rights reserved.
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