期刊
MEDIATORS OF INFLAMMATION
卷 2020, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2020/9273241
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资金
- National Natural Science Foundation of China [81500007]
- Natural Science Foundation of Guangdong Province [2019A1515011713]
- Medical Science and Technology Foundation of Guangdong Province [A2016278, A2018123]
- Group-type Special Supporting Project for Educational Talents in Universities [4SG19221, 4SG19218]
- Research Foundation of Guangdong Medical University [B2019038]
- Key Cultivation Project of Guangdong Medical University [GDMUZ2019001]
Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly <= 5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-infected HFMD cases lead to severe complications such as aseptic meningitis, encephalitis, acute flaccid paralysis, pulmonary edema, cardiorespiratory complication, circulatory disorders, poliomyelitis-like paralysis, myocarditis, meningoencephalitis, neonatal sepsis, and even death. The mechanism of EV71 pathogenesis has been studied extensively, and the regulation of host immune responses is suspected to aggravate EV71-induced severe complications. Recently, several cytokines or chemokines such as TNF-alpha, IFN-gamma, IL-1 beta, IL-18, IL-33, IL-37, IL-4, IL-13, IL-6, IL-12, IL-23, IL-27, IL-35, IL-10, IL-22, IL-17F, IL-8, IP-10, MCP-1, G-CSF, and HMGB1 have been reported to be associated with severe EV71 infection by numerous research teams, including our own. This review is aimed at summarizing the pathophysiology of the cytokines and chemokines with severe EV71 infection.
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