期刊
CALCIFIED TISSUE INTERNATIONAL
卷 100, 期 2, 页码 184-192出版社
SPRINGER
DOI: 10.1007/s00223-016-0209-4
关键词
Skeletal muscle; Bone; Myokines
资金
- Faculty Research Grant of Hong Kong Baptist University [FRG2/13-14/006]
- Hong Kong General Research Fund [12136616, 12102914, 478312]
- Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University [RC-IRMS/13-14/02, RC-IRMS/13-14/03]
- Research Committee of Hong Kong Baptist University [30-12-286, FRG2/14-15/021, FRG2/12-13/027]
- Science and Technology Innovation Commission of Shenzhen Municipality [SCM-2013-SZTIC-001]
- Natural Science Foundation Council [81272045, 81401833, 81572195]
Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1 alpha-irisin system and osteoglycin (OGN). To better understand the molecular communication from skeletal muscle to bone, we have summarized the recent advances in muscle-derived cytokines regulating bone metabolism in this review.
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