期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.110118
关键词
Hydrogel dressings; Hemostasis activity; Bacterial barrier activity; Anti-protein absorption; Full-thickness defects; Immnohistochemical staining
资金
- National Natural Science Foundation of China [21838009, 21606179, 21576223, 21576160]
- Shaanxi Key Laboratory of Degradable Biomedical Materials Program [16J5106, 2015SZSj42, 2014SZS07P05]
Wound recovery is a complex process which is influenced by many factors. Therefore, dressings with multifunctions can greatly promote wound healing. In this study, a series of multifunctional PVA/HLC/SA composite hydrogels with air permeability, anti-protein absorption, bacterial barrier property and hemostasis activity were synthesized in the prospect of producing wound dressings by repeated freeze-thawing of poly (vinyl alcohol), Human-like collagen (HLC) and sodium alginate (SA) with Tween80 added as porogen. Infrared spectrometry (FT-IR) and scanning electron microscope (SEM) clarified its homogeneous porous and interconnected internal structures. In addition, the hydrogels were characterized statistically and in vivo full-thickness defects in rabbit was done to verify their effect on wound healing. Two of the hydrogels (gel 2 and gel 3) showed excellent water vapor transmission rate (2420.97 and 2798.09 g.cm(-2).d(-1)), their swelling ratio were 1427.44 and 2308.24% respectively, worked together with hemostasis property (hemostasis time of gel 2 and gel 3 were 30.55 and 17.33 s respectively), anti-protein absorption and bacterial barrier activity, greatly promoted the full-thickness wound healing in rabbit, wounds of the hydrogel dressing groups took only 10 days to heal, while the control groups need 13-15 days. In a whole, the results facilitate the use of provided hydrogel dressings as ideal wound dressings.
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