期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.110782
关键词
Polyetheretherketone (PEEK); Layer-by-layer deposition; Brushite (CaHPO4 center dot 2H(2)O); Dual-function; Anti-infection; Osseointegration
资金
- National Science Foundation of China [21405016, 81641097]
- Joint Funds for the Innovation of Science and Technology, Fujian Province [2017Y9121, 2017Y9042]
- Natural Science Foundation of Fujian Province of China [2017J01328]
- Elite Cultivation Program of Health and Family Planning of Fujian Province [2017-ZQN-61]
- Medical Innovation Program of Fujian Province [2018-CXB-8]
Polyetheretherketone (PEEK) is an ideal implant material for orthopedic and dental application due to its high biocompatibility and mechanical property. However, biological inertness of PEEK hinders the effective clinical applications in treating bone defect, especially in the situation accompanied by bacterial infection. In this study, a layer-by-layer (LBL) deposition method with controlled cycles was developed to rapidly construct brushite (CaHPO4 center dot 2H(2)O) (CaP) layers containing gentamicin sulfate (GS) on PEEK to obtain CaP-and-GS modified PEEK, named as PEEK/CaP-GS. Different PEEK/CaP-GS, like PEEK/CaP-GS*3, PEEK/CaP-GS*6 and PEEK/CaP-GS*9 were conveniently prepared by repeating the LBL cycles to 3, 6 and 9 times, respectively. The morphology, structure and surface property of the fabricated PEEK/CaP-GS were carefully characterized. In vitro antibacterial experiments illustrated that all of the PEEK/CaP-GS samples had excellent and sustained antibacterial property. Cell proliferation experiments revealed the acceptable biocompatibility and cell osteogenic differentiation of PEEK/CaP-GS, especially in PEEK/CaP-GS*6. X-ray, mu-CT, and histological analysis showed that PEEK/CaP-GS exhibited in vivo antibacterial activity and osseointegration ability in the treatment of bone defect with infection. In both the in vitro and the in vivo experiments, PEEK/CaP-GS*6 prepared from the 6 LBL cycles exhibited the best antibacterial and osseointegration ability for bone healing. This work opens new avenue of the facile and effective modification of PEEK with special biological functions for clinical application, especially for the implants requiring excellent antibacterial and osseointegration ability.
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