期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.110153
关键词
Poly(citrate-siloxane); Bioactive glass; Elastomeric scaffolds; Bone regeneration
资金
- National Natural Science Foundation of China [51872224]
- Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2018LHM-KFKT004]
- Special Guidance Funds for the Construction of World-class Universities
- Characteristic Development in Central Universities [PY3A078]
- Fundamental Research Funds for the Central Universities [xzy022019050]
- Science and Technology Innovation Team Project of Foshan [2015IT100062]
Three dimensional (3D) printed porous bioactive glass nanoparticles scaffolds (BGNS) exhibit excellent bone integration and bone regeneration capacities, but the early rapid ion release, brittle mechanical properties and lack of functions limit their application. In this work, photoluminescent biomimetic elastomeric BGNS were fabricated by directly assembling poly(citrate-siloxane) (PCS) on the surface of BGNS (BGNS@PCS). The morphologies, mechanical behavior, photoluminescent ability, ions release, biomineralization activity, biocompatibility and osteogenic properties of BGNS@PCS were evaluated in detail. The results indicated that BGNS@PCS presented superior elasticity and outstanding compressive strength compared with BGNS. The controlled release of the Si and Ca ions in BGNS@PCS was achieved and enhanced biomineralization ability was also observed. In addition, the modified scaffolds have the photoluminescent ability which has the potential application for bioimaging. BGNS@PCS could significantly promote cells attachment, proliferation and enhance osteogenic differentiation of mouse bone marrow stromal cells (BMSCs). Therefore, the BGNS@PCS with the multifunctional properties including elastomeric surface, enhanced photoluminescent, controlled ions release and biomineralization, reinforced osteogenic activity, would be a promising candidate for bone tissue regeneration. This study probably provides a novel strategy to design biomimetic elastomeric bioceramic scaffolds for hard tissue regeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据