期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.110083
关键词
Sequential electrospinning; Wound healing; Diabetic chronic wounds; Bioglass; Spatially designed multilayer structure
资金
- National Key Research and Development Program of China [2017YFC1105000]
- National Natural Science Foundation of China [81672226]
- Science and Technology Research Funding of Shenzhen [JSGG20180503182359108, JCYJ20170413162540673]
- Guangdong Provincial Science and Technology project [2016A020222007]
Cutaneous wounds, especially chronic wounds, remain clinical challenges, and this is partially due to the complex healing process composed of four overlapping but distinct stages including hemostasis, inflammation, proliferation and remodeling. Therefore, wound dressings with spatially designed structures which can temporally regulate certain bioactive components to function at specific healing stages might be able to accelerate the healing process. In this study, nanobioglass incorporated chitosan-PVA (polyvinyl alcohol) trilayer nanofibrous membrane (nBG-TFM) was fabricated via sequential electrospinning. This membrane exhibited excellent biocompatibility, antibacterial activity and regeneration promotion effect. Furthermore, spatially designed structure optimized functions of each component and provided more suitable microenvironment as compared with uniform membrane. Rat full-thickness skin defects model and mice diabetic chronic wound model showed that nBG-TFM could achieve significantly accelerated and enhanced healing, in terms of complete re-epithelialization, improved collagen alignment and formation of skin appendages. It was revealed that nBG-TFM functioned through upregulating growth factors including VEGF and TGF-beta. Meanwhile inflammatory cytokines such as TNF-alpha and IL-1 beta were downregulated. The technology presented in this study shed new light on designing functional wound dressings which can promote healing of chronic wounds.
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