期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.110195
关键词
Thermosensitive hydrogels; Bone tissue engineering; Green synthesis; Antibacterial properties; Corn silk extract
资金
- Italian Ministry of Foreign Affairs and International Cooperation in the frame of the Executive Program of Scientific and Technological Cooperation between Italy and Egypt
Injectable hydrogels have revealed the great potential for use as scaffolds in cartilage and bone tissue engineering. Here, thermosensitive and injectable hydrogels containing beta-tricakium phosphate, hyaluronic acid, and corn silk extract-nanosilver (CSE-Ag NPs) were synthesized for their potential use in bone tissue regeneration applications. Spherical nanoparticles of silver were biosynthesized through microwave-assisted green approach using CSE in organic solvent-free medium. Rheological experiments demonstrated that the thermosensitive hydrogels have gefification temperature (T-gel) close to body temperature. The samples containing Ag NPs showed antibacterial activity toward gram-positive (Bacillus Subtilis, Staphylococcus Aureus) and gram-negative (Pseudomonas Aeruginosa, Escherichia Colt) bacteria along without cytotoxicity after 24 h. Mesenchymal stem cells seeded in the nanocomposite exhibited high bone differentiation which indicate that thay could be a good candidate as a potential scaffold for bone tissue regeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据