期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 79, 期 7, 页码 1164-1171出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2015.1018123
关键词
obesity; soybean isoflavone; cholecystokinin-1 receptor (CCK1R); appetite; leptin receptor (ObRb)
类别
资金
- Uehara Memorial Foundation
- Fuji Foundation for Protein Research
- Ministry of Education, Science, Sports, and Culture of Japan
We investigated the effect of daidzein feeding and estradiol treatment on food intake in cholecystokinin-1 receptor (CCK1R) deficiency, leptin receptor (ObRb) deficiency rats and their wild-type rats. These rats underwent an ovariectomy or a sham operation. For the 5 week experiment, each rat was divided in three groups: control, daidzein (150mg/kg diet), and estradiol (4.2 mu g/rat/day) groups. In both CCK1R+ and CCK1R- rats, daidzein feeding and estradiol treatment significantly decreased food intake. Daidzein feeding significantly reduced food intake in ovariectomized ObRb- rats, although not in ObRb+ rats. Estradiol treatment significantly lowered food intake in ovariectomized ObRb+ and ObRb- rats. In the ovariectomized rats, estradiol treatment significantly increases uterine weight, while daidzein feeding did not change it, suggesting that daidzein might have no or weak estrogenic effect in our experiment. These results suggest that CCK1R and ObRb signalings were not essential for the daidzein- and estradiol-induced anorectic action.
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