期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.110377
关键词
Antibacterial; Carbon quantum dots; Nanofiber; Photodynamic inactivation; Electrospinning
资金
- National Key R&D Program of China [2017YFB0309100]
- Key Laboratory of Eco textiles, Ministry of Education - Fundamental Research Funds for the Central Universities [JUSRP51907A]
- national first-class discipline program of Light Industry Technology and Engineering [LITE2018-21]
- Natural Science Foundation of Jiangsu Province [BK20180628]
- National Natural Science Foundation of China [51803078]
- 111 Project [B17021]
- International Science and Technology Center [BZ2018032]
Faced with the emergence and proliferation of antibiotic resistant pathogens, novel nonspecific materials and approaches are required. Herein, we employed electrospinning technology to fabricate nanofibers with antibacterial photodynamic inactivation. This material combines polyacrylonitrile, as a photostable polymer, and biocompatible carbon quantum dots. The resulted nanofibers were successfully characterized by physical and spectroscopic methods. The microbicidal reactive oxygen species (i.e., singlet oxygen) upon illumination was confirmed, and cytotoxicity assay demonstrated that the nanofibers had low cytotoxicity and good biocompatibility. Antibacterial photodynamic inactivation studies demonstrated broad antibacterial efficacy of Gram-negative Escherichia colt ATCC-8099 (99.9999 + %, 6 log units inactivation), Gram-negative Pseudomonas aeruginosa CMCC (B) 10104 (99.9999 +%, 6 log units inactivation), and Gram-positive Bacillus subtilis CMCC (B) 63501 (99.9999 +%, 6 log units inactivation) upon illumination with visible light (Xe lamp, 500 W, 12 cm sample distance, lambda >= 420 nm, 1.5 h). However modest inactivation results were observed against Gram-positive Staphylococcus aureus ATCC-6538 (98.3%, 1.8 log units inactivation). Owing to the prepared nanofibers exhibiting efficient antibacterial activity against Gram-negative and Gram-positive bacteria, such materials could be potentially used in anti-infective therapy.
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