期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.110334
关键词
Photoactivated release; Smart nanomaterials; Bactericide material; Silver nanoparticles; Electrospinning
资金
- Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP) from Brazil [2017/12174-4]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), MCTI-SisNano from Brazil [CNPq/402.287/2013-4]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) from Brazil [001]
- Rede Agronano-EMBRAPA from Brazil
Smart nanomaterials activated by light is one of the most exciting strategies to control the release of substances in varied environments. Here we developed a smart nanomaterial composed by a photoresponsive nanogel containing silver nanoparticles (AgNps) immobilized on the surface of biodegradable and biocompatible polycaprolactone (PCL) nanofibers mats produced by electrospinning. The AgNps are released from the nanogel and dispersed inside the nanofiber mats when this system is irradiated by light at 405 nm. This light excites the plasmonic band of the AgNps, which breaks the nanogel and, as a consequence, releases the AgNps on the nanofibers. Consequently, this AgNps release mechanism controls the propagation of silver ions by the application of light. Different configurations of antibacterial nanofibers mats, including neat PCL nanofibers and PCL nanofibers modified with AgNps-Nanogels and AgNps, excited by laser light at 405 nm, were investigated regarding antibacterial properties. The best result was achieved using PCL nanofiber mats functionalized with AgNps and AgNps-Nanogels after light exposure, which generated inhibition diameters of 2.6 +/- 0.3 mm and 1.8 +/- 0.5 mm for S. aureus and E. coli, respectively. The smart nanomaterial developed here is a promising material for clinical application as wound dressing activated by light.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据