期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.110033
关键词
TEMPO-oxidized cellulose nanofiber (TOCN); Nanostructured particle; Silica; Lysozyme; Cellulose nanofiber (CNF)
资金
- JSPS KAKENHI [19H02500]
- JSPS Core-to-Core Program
- Hosokawa Powder Technology Foundation
- Mazda Foundation
- Electric Technology Research Foundation of Chugoku
- Japanese Ministry of Education, Culture, Sports, Science, and Technology (MEXT)
- Center for Functional Nano Oxide at Hiroshima University
- Information Center of Particle Technology, Japan
Effective protein adsorption has attracted attention for broad application in the biomedical field. In this study, we introduce the synthesis of a TEMPO-oxidized cellulose nanofiber (TOCN) decorated macroporous SiO2 (TOCN@macroporous SiO2) particle and its protein adsorption performance. The TOCN@macroporous SiO2 particles have a unique cellulose nanofiber network structure on the macroporous, highly-negative zeta potential (-62 +/- 2 mV) and high surface area (30.8 m(2)/g) for dried-state cellulose based particles. These characteristics provide sites that are rich in electrostatic interaction to exhibit an outstanding adsorption capacity of lysozyme (1865 mg/g). Furthermore, the TOCN@macroporous SiO2 particles have remarkably high reusability (>90% adsorption capacity) and good release of adsorbate (>80%) after 10 times of use. The material proposed in this paper has the potential for application in drug delivery, protein adsorption, biosensors, and other biomedical fields.
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