期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.110486
关键词
Surface modification; PLLA scaffold; Interfacial bonding; Mechanical properties; Degradation behavior
资金
- Natural Science Foundation of China [81871494, 81871498, 51705540]
- Hunan Provincial Natural Science Foundation of China [2018JJ3671, 2019JJ50588]
- Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme (2018)
- Open Sharing Fund for the Large-scale Instruments and Equipments of Central South University
- Project of Hunan Provincial Science and Technology Plan [2017RS3008]
- Science and Technology Planning Project of Shenzhen Municipality [JCYJ20170817112445033]
- National Postdoctoral Program for Innovative Talents [BX201700291]
- China Postdoctoral Science Foundation [2018M632983]
The poor interfacial bonding and resultant agglomeration of nanoparticles in polymer-based composite severely deteriorated their reinforcement effect. In this work, MgO nanoparticles (MgO-NPs) were surface modified with Poly (L-lactic acid-co-malic acid) (PLMA) to improve the interfacial compatibility in Poly-l-lactic acid (PLLA) scaffold manufactured by selective laser sintering. PLMA possess a hydrophilic end with carboxyl group (comes from the malic acid) and an I-lactic acid chain. On one hand, the carboxyl group was able to form hydrogen bonding with the hydroxyl groups of MgO-NPs. On the other hand, the l-lactic acid chain containing the hydroxyl groups could react with the carboxyl group of PLLA. Results revealed that the scaffold exhibited significantly enhanced compressive strength and modulus by 47.1% and 237.7%, respectively, which could be ascribed to the enhanced interfacial bonding between PLLA and MgO-NPs, as well as the rigid particle reinforcement. In addition, the scaffold was favorable for cell adhesion, proliferation and differentiation, owing to the improved hydrophilic and suitable pH environment. It was suggested the scaffold was a promising material for bone repair application.
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