期刊
MARINE DRUGS
卷 17, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/md17120682
关键词
marine sponge; Haliclona; symbiotic microbe; secondary metabolite; alkaloid; bioactivity
资金
- National Natural Science Foundation of China [41776139, 81773628]
- Fundamental Research Fund for the Provincial Universities of Zhejiang [RF-C2019002]
Marine sponge genus Haliclona, one of the most prolific sources of natural products, contains over 600 species but only a small part of them had been classified and chemically investigated. On the basis of extensive literature search, this review firstly summarizes 112 nitrogenous secondary metabolites from classified and unclassified Haliclona sponges as well as from their symbiotic microorganisms. Most of these substances have only been found in Haliclona sponges, and display diverse bioactive properties with potential applications in new drug discovery.
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