期刊
MARINE DRUGS
卷 17, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/md17120698
关键词
pyrazinone; marine-derived myxobacterium; Enhygromyxa sp
资金
- University of Wisconsin-Madison School of Pharmacy
- National Institutes of Health grants [U19AI109673, U19AI142720]
- NIH [P41RR02301, P41GM66326]
To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wide array of biological activities. Marine-derived myxobacteria are especially attractive due to their unique biosynthetic gene clusters, although they are more difficult to handle than terrestrial myxobacteria. Here, we report the discovery of two new pyrazinone-type molecules, enhypyrazinones A and B, from a marine-derived myxobacterium Enhygromyxa sp. Their structures were elucidated by HRESIMS and comprehensive NMR data analyses. Compounds 1 and 2, which contain a rare trisubstituted-pyrazinone core, represent a unique class of molecules from Enhygromyxa sp.
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