期刊
LIPIDS
卷 55, 期 3, 页码 279-284出版社
WILEY
DOI: 10.1002/lipd.12224
关键词
Autotaxin; Brown adipose tissue; Fasting; Lysophosphatidic acid; Lysophosphatidic acid receptors; White adipose tissue
资金
- Canada Foundation for Innovation Funding Source: Medline
- Canada Foundation for Innovation - Leader's Opportunity Fund [30259] Funding Source: Medline
- Natural Sciences and Engineering Research Council of Canada [Discovery Grant 418213-2012] Funding Source: Medline
- - Leader's Opportunity Fund [30259] Funding Source: Medline
- Ontario Ministry of Research, Innovation and Science [Early Researcher Award ER16-12-162] Funding Source: Medline
Lysophosphatidic acid (lysoPtdOH) levels have previously been reported to decrease in rodents with short-term fasting. We investigated whether a 16 h fast would change expression of autotaxin, the predominant phospholipase D responsible for adipose-derived lysoPtdOH synthesis, or any of the lysophosphatidic acid receptors (1-6) in four white adipose tissue (WAT) depots and interscapular brown adipose tissue (BAT) in male C57Bl/6J mice fed ad libitum, or fasted for 16 h. Aside from small inductions of Lpar1 in epididymal WAT and Lpar2 in epididymal and inguinal WAT, no significant changes were observed in expression of the Lpar family members, or autotaxin in perirenal, retroperitoneal, epididymal, or inguinal WAT or BAT with fasting. Comparison of the relative expression of Lpar1-6 in various depots showed that Lpar6 was the predominant Lpar in both WAT and BAT, and suggests that further work on the adipose-specific role of Lpar6 is warranted.
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